HRF at a Glance
The experts at Hippocrates Research Foundation have years of experience successfully reversing chronic diseases when standard of care medicine has failed. Most chronic diseases can be traced back to mitochondrial dysfunction and insufficient cellular energy production. Through thousands of years of evolution the human body has been hardwired to heal itself if adequate amounts of energy are available. Proper diet, exercise, supplements, pulsed electromagnetic fields, red light therapy and hyperbaric oxygen are a few of the metabolic interventions proven to improve mitochondrial function and energy production. The criteria for interventions at HRF is “First do no Harm.”
Recently, the experts at HRF realized most all of their metabolic therapies used to increase mitochondrial function could be traced back to increasing molecular hydrogen and decreasing deuterium or "heavy hydrogen". For instance, the supplements psyllium, inulin, and galactose greatly increase molecular hydrogen production from the gut microbiome. A ketogenic diet with a decrease in sugar consumption also decreases deuterium levels. We suspect hyperbaric oxygen lowers deuterium levels, but this has yet to be confirmed in published literature. There are over 3000 articles published in peer reviewed medical journals detailing the therapeutic mechanisms of action for molecular hydrogen and deuterium depletion. Hydrogen is the most perfect antioxidant, small enough to repair DNA, increase mitochondrial function, and facilitate many crucial chemical reactions. Deuterium (heavy hydrogen) is naturally occurring and facilitates cell replication. However, excess deuterium negates the positive effects of molecular hydrogen and is associated with all chronic diseases, including cancer.
Research shows no side effects from increasing molecular hydrogen and decreasing deuterium. Diseases ranging from metabolic syndrome, obesity, Parkinson’s, Alzheimer’s, cancer, and even ALS have been positively effected by increasing molecular hydrogen and decreasing deuterium levels. We believe this mechanism of action is responsible for much of the success of Thomas Seyfried’s Press-Pulse Protocol. HRF is using this knowledge to decrease the cost and improve compliance with the Press Pulse Protocol. These two metabolic therapies can also be combined with standard of care therapy to enhance the therapy and decrease side effects.
HRF believes we are at the point with cancer where HIV and AIDS were 40 years ago. Liquid biopsies are available today for very early cancer detection, years before clinical manifestation. We have been able to monitor and keep circulating cancer cells in check, which could eventually lead to the prevention of most cancers through optimization of cellular health. Research is needed to validate and replicate the initial work on a larger patient population and among patients with different types of cancer.
At this time Hippocrates Research Foundation does not have the staff to work directly with patients. We are doing our best to raise funds which will allow us to hire more staff, train physicians, conduct clinical studies, and most immediately update our website to better serve. In the future HRF desires to have a list of certified healthcare professionals to assist in optimizing health, and “First do no Harm.”
Starving Cancer: Breaking Down Thomas Seyfried's Radical & Controversial Protocol
In January of 2024, HRF was on the Dhru Purohit Podcast with our first patient that we helped reverse his Stage 4 cancer using Thomas Seyfried's Press-Pulse Protocol. Since that time we better understand the mechanism of action of the success of this method. The ketogenic diet has been shown to reduce the deuterium levels in the body in conjunction with increasing molecular hydrogen. We hope that further studies will support these theories in improving health and wellness and aid the body in fighting disease processes at a molecular level, in particular, improving mitochondrial function.
First, do no harm to the patient. HRF researches the mechanisms by which patients can optimize their health span and athletic performance
Michelle's Stage Zero Cancer Story
After a possible breast cancer scare the year before, Michelle decided to have a liquid blood biopsy to look for circulating cancer cells. Unfortunately it came back positive for two cancers- malignant melanoma and ovarian cancer. The melanoma was not completely unexpected as one was removed about 20 years earlier, although follow up “studies” had always been negative. The ovarian was a surprise. She opted to have her ovaries removed. Not surprisingly, no tumor was found in the ovarian tissue. After all, this was Stage Zero Cancer- found when there were only a few circulating cancer stem cells- she didn’t wait for the tumor to develop. For the melanoma, it was going to be difficult to find the abnormal pigmented lesion- she was covered with freckles! But after reading studies and case reports, she and her dermatologist decided to sequentially apply an immune modulator cream to stimulate her own cells to attack abnormal skin cells. It finally produced a response on the chest area, which blistered and healed.
Follow up was done routinely with a Nagalase blood test. This test measures an enzyme that breaks down certain glycoproteins (sugars attached to proteins) and glycolipids (sugars attached to fats), and can be elevated in cancer and viral infections, among other things. Although it is not a specific diagnostic test for cancer, it can be used to follow the effect of therapy on certain cancer types and viral infections. In addition, liquid blood biopsies were also done periodically to assess and monitor the overall cancer stem cell number, as well as an epigenetic analysis of the cancer stem cells (I.e. was there a tendency for the cells to develop their own blood supply?)
Based on the growth/ suppression of my cancer stem cells in 120 different anti-cancer drugs and targeted therapies, Michelle began a series of supplements and the ketogenic diet (cancer loves sugar!). Then the response to the different supplements and diet were assessed by the Nagalase value.
The ketogenic diet was helpful, but not a good long term solution. Some supplements decreased the Nagalase number to normal, but overtime it began to creep up again. Apparently cancer cells are adaptable, and appear to be able to mutate or change in some way to get around the treatment being administered. This seemed to indicate a need to try multiple modalities and supplements in a rotating fashion- there was no “one size fits all” approach that was going to be effective, or even a “one and done” treatment. She would have to learn to live with cancer- much like a diabetic lives with constant blood sugar monitoring or a hypertensive patient lives with blood pressure monitoring.
It is a continuing work in progress, trying different supplements and treatment modalities and assessing the effect with periodic Nagalase blood tests and liquid blood biopsies. But she does so while living her life: family, work and Ironman training.
Patient Den Stacey before the Press-Pulse protocol.
Patient Den Stacey after the Press-Pulse protocol.
Resolving Pulmonary Artery Intimal Sarcoma via the Standard of Care combined with Metabolic Therapies
Den Stacey was the first patient that approached HRF to help address his Pulmonary Artery intimal sarcoma after surgical resection, using metabolic therapies and avoiding chemotherapy or radiation. After surgical resection, Den identified Thomas Seyfried and his Press-Pulse Protocol, who referred him to HRF to help him further implement the components. After months of a strict diet, thrice weekly Hyperbaric Oxygen treatments and adding supplements and DON, his scans showed resolution of the lung metastases and No Evidence of Disease (NED) on follow up PET scans. Throughout the therapy Den has been instrumental in identifying helpful tactics to address a variety of minor side effects (I.e. gastrointestinal) that have been instrumental in achieving success with the Press-Pulse Protocol.
David Daniels Before Picture
Patient with Type II Diabetes Mellitus and Cardiac Disease
For years David struggled with Type II Non-insulin dependent diabetes and a very high Lipoprotein an and an elevated cholesterol, about seven years before his first heart attack. His doctor told him that his Type II diabetes was genetic and not reversible, and also did not want to treat or address the elevated Lipoprotein a. He began to have almost one heart attack a year, requiring cardiac stents, inside a stent, inside a stent. After working with Hippocrates Research Foundation on a ketogenic diet and wearing a continuous glucose monitor, David lost almost 50 pounds and reversed his diabetes. He was enrolled in a study to address the Lipoprotein a, but unfortunately he was assigned to the placebo. He quit the study and is now taking a new drug to lower his Lipoprotein a. Since working with HRF, David no longer has diabetes or any further heart attacks.
David Daniels After Picture
"Great things are done by a series of small things brought together"
Vincent van Gogh
Contact HIPPOCRATES RESEARCH FOUNDATION with your questions
1790 Hughes Landing Blvd, Suite 400, The Woodlands, Texas 77389
Hippocrates Research Foundation
Pursuing the study of dysfunction at the intersection of metabolism and disease. We invite your help in being a catalyst that helps our community members reach their goals and fulfill their potential.